Eradication of Helicobacter Pylori Bacteria Using Probiotics and Prebiotics in Compare with Antibiotics in Al-Jumail city

Abstract

Background: Helicobacter pylori bacteria is a bacteria that colonize gastric mucosa, it can cause gastritis and may also lead to serious complications such as ulcers and even stomach cancer. Probiotics are living beneficial bacteria that contribute to the eradication of H. Pylori bacteria by several mechanisms. Prebiotics are non-digestible carbohydrates and it is the complement to probiotics, they are the feed for probiotics. Synbiotic is a term used to describe the food that contains both probiotics and prebiotics, this combination work better in the eradication of H. Pylori bacteria.

Aims: the main aim of this research is to compare between the probiotics, prebiotics, synbiotics, and antibiotics in the eradication of H. Pylori bacteria, another aim is to evaluate the role of probiotics in the standard triple Helicobacter pylori therapy.

 Methods: in current research which was conducted in Al-Jumail city, 13 adult volunteers were enrolled. 3 of them underwent triple therapy for 7-10 days, as control subjects. The others were grouped into three groups, group (a) received the same 7-10 days triple therapy plus yogurt for 3 weeks, group (b) received a prebiotic supplement for one week, the group (c) received yogurt with garlic (Synbiotic) for one week.     H. Pylori eradication was checked by a blood test (IgG). Data was analyzed by SPSS program.

Results: reduction rate of blood IgG level, which represents the eradication rate of H. pylori bacteria, was higher in synbiotics group (1.12) (p=0.068), compared to other groups, which were:

(0.98) for antibiotic + yogurt (p=0.285). 

(0.79) for antibiotics (p=0.109).

(0.17) for prebiotics (p=0.593). 

Conclusion: Synbiotic therapy, represented by yogurt with garlic, is the best choice to eradicate H. Pylori bacteria when taken regularly.