Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anti-breast cancer Agents

Abstract

Using creative, effective anticancer therapeutics, new kinds of heteroaryl pyrazoline compounds were synthesized, designed, and studied based on their anti-proliferative effects against breast cancer cell lines. The following pyrazoline derivatives were designed and synthesized: 5-(naphthalene-2-yl)-3-(phenyl)-1-tosyl-1H-pyrazole (NAPT) and 3-(4-N,N-dimethylamino)-phenyl)-5-(naphthalene-2-yl)-1-tosyl-1H-pyrazole (DMNAPT) Using naphthyl-chalcone derivatives, pyrazoline derivatives were synthesized and were determined using IR and ¹H-NMR spectra. Antitumor activity was also evaluated using the MTT assay. It was discovered that the compounds synthesized from 2-naphthyl chalcones (M1 and M2) exhibited relatively better anti-proliferative activity against MCF-7 breast cancer cells. Among the compounds that were evaluated, NAPT and DMNAPT were observed to have significantly moderate anti-proliferative activity on the MCF-7.