Vitamin D3, C, E and Sialic acid in Serum of Hyperuricemia Patients

Abstract

Hyperuricemia is commonly diagnosed with abnormal purine metabolism. Prolonged hyperuricemia often associated with gout, which is a vital risk factor for joint dysfunction. Our study aimed to determine the bidirectional association between vitamins (D₃, C, E) and sialic acid in hyperuricemia patients, which assessed the association between serum uric acid and vitamins measured in this study. Materials and methods: The study was conducted on 98 blood samples were collected from males and females at a ratio (1:1), 48 of which were control subject and 48 of which were from patients with hyperuricemia, whose age ranged from (25 years and above), during a period from September  to December 2021, from Al-Salam Teaching Hospital in Mosul city, Iraq, serum samples were separated and stored in capped tubes, then we measured the level of (D₃, C, E) and sialic acid.  The results indicated that the level of vitamin D₃ and E decreased in hyperuricemia patients (the differences between control subjects and hyperuricemia patients were significant at (p≤ 0.05), but vitamin C and sialic acid increased significantly at (p≤ 0.05) compared to control subject.