Effect of Moringa Extract Against Renal Injury Caused by High Fat Diet-Induced Obesity in Male Rats

Abstract

This research endeavor delved deeply into the potential protective efficacy of moringa extract in ameliorating renal impairments instigated by a high-fat dietary regimen in male rat models. The subjects were judiciously classified into six discrete cohorts, each comprising six individuals, with the subsequent allocation: Group 1 serving as the non-intervention control; Group 2 receiving a daily dose of 300 mg/kg body weight moringa extract (ME) spanning 8 weeks; Group 3 subjected to a sustained high-fat diet (HFD) throughout an 8-week interval; Group 4 exposed to a dual-modality involving an HFD and daily administration of 300 mg/kg bw ME for the identical duration; Group 5 subjected to the combined impact of an HFD and a daily 40 mg/kg bw dose of simvastatin (SIM) across 8 weeks; lastly, Group 6 subjected to a concurrent treatment approach involving an HFD, 300 mg/kg bw ME, and 40 mg/kg bw SIM, daily, over an 8-week period. Through an intricately orchestrated sequence of experiments, we embarked upon an expedition to unearth the Reno protective potential of moringa extract against dietary-induced nephrological impairment. Our findings offer an all-encompassing outlook on the synergy between dietary interventions and the innovative agents under scrutiny. This inquiry not only advances our comprehension of potential remedies for diet-associated renal adversities but also accentuates the emergence of moringa extract as a formidable contender in this domain. Our revelations illuminated that the application of a high-fat diet ushered in a substantial surge in malondialdehyde (MDA) levels, emblematic of heightened oxidative stress. This was concomitant with a marked depletion in glutathione (GSH), aggregate antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GSH-Rd) levels. Conversely, the administration of moringa extract adeptly mitigated these adverse repercussions induced by the high-fat dietary regimen.